Mouse BTLA protein (Recombinant) (C-hFC) (STJP002828)

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STJP002828
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Short Description :Recombinant-Mouse BTLA-C-hFC protein was developed in hek293 cells using the region Glu30-Pro176. For use in research applications.
Host:HEK293 cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Formulation:Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:<0.1 EU/Mu g
Gene Symbol:Btla
Gene ID:208154
Uniprot ID:BTLA_MOUSE
Immunogen:Recombinant Mouse BTLA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu30-Pro176) of mouse BTLA (Accession #NP_001032808.2) fused with a hFc tag at the C-terminus.
Immunogen Region:Glu30-Pro176
Immunogen Sequence:EKATKRNDEECPVQLTITRN SKQSARTGELFKIQCPVKYC VHRPNVTWCKHNGTICVPLE VSPQLYTSWEENQSVPVFVL HFKPIHLSDNGSYSCSTNFN SQVINSHSVTIHVRERTQNS SEHPLITVSDIPDATNASGP STMEERP
Post Translational Modifications Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated.
Function Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Protein Name B- And T-Lymphocyte Attenuator
B- And T-Lymphocyte-Associated Protein
Cd Antigen Cd272
Database Links Reactome: R-MMU-9927353
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names B- And T-Lymphocyte Attenuator protein
B- And T-Lymphocyte-Associated Protein protein
Cd Antigen Cd272 protein
Btla protein

Information sourced from Uniprot.org

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