Mouse CD24 protein (Recombinant) (C-hFc) (STJP001430)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse CD24 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn27-Gly53) of mouse CD24 (Accession #NP_033976.1) fused with a hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse CD24-C-hFc protein was developed in hek293 cells using the region Asn27-Gly53. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA.Immobilized Human CD24 at 2 Mu g/mL (100 Mu L/well) can bind Human Siglec10 with a linear range of 40-900ng/mL. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | Cd24 |
| Gene ID | 12484 |
| Uniprot ID | CD24_MOUSE |
| Immunogen | Recombinant Mouse CD24 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn27-Gly53) of mouse CD24 (Accession #NP_033976.1) fused with a hFc tag at the C-terminus. |
| Immunogen Region | Asn27-Gly53 |
| Immunogen Sequence | NQTSVAPFPGNQNISASPNP SNATTRG |
Additional Info
| Post Translational Modifications | The identity of the N- and O-linked polysaccharides is not reported in PubMed:1530634. The O-linked polysaccharides on Ser-30, Ser-41, Ser-43, and Thr-51 are probably the mucin type linked to GalNAc. |
| Function | May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity. |
| Protein Name | Signal Transducer Cd24Lymphocyte Antigen 52Ly-52M1/69-J11d Heat Stable AntigenHsaNectadrinR13-AgX62 Heat Stable AntigenCd Antigen Cd24 |
| Database Links | |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Protein Names | Signal Transducer Cd24 proteinLymphocyte Antigen 52 proteinLy-52 proteinM1/69-J11d Heat Stable Antigen proteinHsa proteinNectadrin proteinR13-Ag proteinX62 Heat Stable Antigen proteinCd Antigen Cd24 proteinCd24 proteinCd24a proteinLy-52 protein |
Information sourced from Uniprot.org