Mouse BTLA protein (Recombinant) (C-hFC) (STJP002828)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse BTLA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu30-Pro176) of mouse BTLA (Accession #NP_001032808.2) fused with a hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse BTLA-C-hFC protein was developed in hek293 cells using the region Glu30-Pro176. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | Btla |
| Gene ID | 208154 |
| Uniprot ID | BTLA_MOUSE |
| Immunogen | Recombinant Mouse BTLA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu30-Pro176) of mouse BTLA (Accession #NP_001032808.2) fused with a hFc tag at the C-terminus. |
| Immunogen Region | Glu30-Pro176 |
| Immunogen Sequence | EKATKRNDEECPVQLTITRN SKQSARTGELFKIQCPVKYC VHRPNVTWCKHNGTICVPLE VSPQLYTSWEENQSVPVFVL HFKPIHLSDNGSYSCSTNFN SQVINSHSVTIHVRERTQNS SEHPLITVSDIPDATNASGP STMEERP |
Additional Info
| Post Translational Modifications | Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated. |
| Function | Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. |
| Protein Name | B- And T-Lymphocyte AttenuatorB- And T-Lymphocyte-Associated ProteinCd Antigen Cd272 |
| Database Links | Reactome: R-MMU-9927353 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | B- And T-Lymphocyte Attenuator proteinB- And T-Lymphocyte-Associated Protein proteinCd Antigen Cd272 proteinBtla protein |
Information sourced from Uniprot.org