Name: Mouse B7-H2/ICOSLG/CD275 protein (Recombinant) (C-His) (STJP002774)
SKU: STJP002774
Availability: InStock

Mouse B7-H2/ICOSLG/CD275 protein (Recombinant) (C-His) (STJP002774)

SKU:

STJP002774

£89.50 - £274.50

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	<0.1 EU/Mu g

Gene Symbol:	Icoslg
Gene ID:	50723
Uniprot ID:	ICOSL_MOUSE
Immunogen Region:	Glu47-Lys279
Immunogen:	Recombinant Mouse B7-H2/ICOSLG/CD275 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu47-Lys279) of mouse B7-H2/ICOSLG/CD275 (Accession #NP_056605.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	ETEVGAMVGSNVVLSCIDPH RRHFNLSGLYVYWQIENPEV SVTYYLPYKSPGINVDSSYK NRGHLSLDSMKQGNFSLYLK NVTPQDTQEFTCRVFMNTAT ELVKILEEVVRLRVAANFST PVISTSDSSNPGQERTYTCM SKNGYPEPNLYWINTTDNSL IDTALQNNTVYLNKLGLYDV ISTLRLPWTSRGDVLCCVEN VALHQNITSISQAESFTGNN TKNPQETHNNELK

Function	Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion.induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (Probable). During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.
Protein Name	Icos Ligand B7 Homolog 2 B7-H2 B7-Like Protein Gl50 B7-Related Protein 1 B7rp-1 Licos Cd Antigen Cd275
Database Links	Reactome: R-MMU-388841
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Isoform 1: Cell Membrane Isoform 2: Cell Membrane
Alternative Protein Names	Icos Ligand protein B7 Homolog 2 protein B7-H2 protein B7-Like Protein Gl50 protein B7-Related Protein 1 protein B7rp-1 protein Licos protein Cd Antigen Cd275 protein Icoslg protein B7h protein B7h2 protein B7rp1 protein Icosl protein

Information sourced from Uniprot.org

Model	Name	Host
STJP002721	Human B7-H2/ICOSLG/CD275 protein (Recombinant) (C-His) (STJP002721)	HEK293 cells
STJP002907	Human B7-H2/ICOSLG/CD275 protein (Recombinant) (C-hFC) (STJP002907)	HEK293 cells
STJP001675	Human B7-H2/ICOSLG protein (Recombinant) (C-His-Avi) {Biotin} (STJP001675)	HEK293
STJP001245	Mouse B7-1/CD80 protein (Recombinant) (C-His) (STJP001245)	HEK293 cells
STJP002739	Mouse B7-2/CD86 protein (Recombinant) (C-His) (STJP002739)	HEK293 cells

Mouse B7-H2/ICOSLG/CD275 protein (Recombinant) (C-His) (STJP002774)