Mouse B7-H2/ICOSLG/CD275 protein (Recombinant) (C-His) (STJP002774)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse B7-H2/ICOSLG/CD275 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu47-Lys279) of mouse B7-H2/ICOSLG/CD275 (Accession #NP_056605.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse B7-H2/ICOSLG/CD275-C-His protein was developed in hek293 cells using the region Glu47-Lys279. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | Icoslg |
| Gene ID | 50723 |
| Uniprot ID | ICOSL_MOUSE |
| Immunogen | Recombinant Mouse B7-H2/ICOSLG/CD275 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu47-Lys279) of mouse B7-H2/ICOSLG/CD275 (Accession #NP_056605.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Glu47-Lys279 |
| Immunogen Sequence | ETEVGAMVGSNVVLSCIDPH RRHFNLSGLYVYWQIENPEV SVTYYLPYKSPGINVDSSYK NRGHLSLDSMKQGNFSLYLK NVTPQDTQEFTCRVFMNTAT ELVKILEEVVRLRVAANFST PVISTSDSSNPGQERTYTCM SKNGYPEPNLYWINTTDNSL IDTALQNNTVYLNKLGLYDV ISTLRLPWTSRGDVLCCVEN VALHQNITSISQAESFTGNN TKNPQETHNNELK |
Additional Info
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion.also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (Probable). During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype. |
| Protein Name | Icos LigandB7 Homolog 2B7-H2B7-Like Protein Gl50B7-Related Protein 1B7rp-1LicosCd Antigen Cd275 |
| Database Links | Reactome: R-MMU-9927354 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 1: Cell MembraneIsoform 2: Cell Membrane |
| Alternative Protein Names | Icos Ligand proteinB7 Homolog 2 proteinB7-H2 proteinB7-Like Protein Gl50 proteinB7-Related Protein 1 proteinB7rp-1 proteinLicos proteinCd Antigen Cd275 proteinIcoslg proteinB7h proteinB7h2 proteinB7rp1 proteinIcosl protein |
Information sourced from Uniprot.org