Mouse Aldehyde dehydrogenase 2/ALDH2 protein (Recombinant) (His-Tag) (STJP019177)
SPECIFICATIONS
HostE.coli
ImmunogenMouse
General Information
| Short Description | Recombinant-Mouse Aldehyde dehydrogenase 2/ALDH2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Aldh2 |
| Gene ID | 11669 |
| Uniprot ID | ALDH2_MOUSE |
| Accession Number | NP_033786 |
| Immunogen | Mouse |
| Immunogen Region | 20-519aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSSAAATSA VPAPNHQPEV FCNQIFINNE WHDAVSRKTF PTVNPSTGEV ICQVAEGNKE DVDKAVKAAR AAFQLGSPWR RMDASDRGRL LYRLADLIER DRTYLAALET LDNGKPYVIS YLVDLDMVLK CLRYYAGWAD KYHGKTIPID GDFFSYTRHE PVGVCGQIIP WNFPLLMQAW KLGPALATGN VVVMKVAEQT PLTALYVA |
Additional Info
| Post Translational Modifications | In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Function | Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. |
| Protein Name | Aldehyde Dehydrogenase - MitochondrialAhd-M1Aldh Class 2Aldh-E2Aldhi |
| Database Links | Reactome: R-MMU-380612Reactome: -MMU-445355Reactome: -MMU-71384Reactome: -MMU-9837999 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Aldehyde Dehydrogenase - Mitochondrial proteinAhd-M1 proteinAldh Class 2 proteinAldh-E2 proteinAldhi proteinAldh2 proteinAhd-1 proteinAhd1 protein |
Information sourced from Uniprot.org