| Tissue Specificity | Highly expressed in salivary glands and pancreatic alpha cells in the adult (at protein level). In the embryo, expressed primarily at sites of tissue remodeling such as ganglia, developing bones and teeth. |
| Post Translational Modifications | Cleaved by caspase-7 in response to apoptosis to produce EMAP-II. |
| Function | Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. |
| Protein Name | Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 1Multisynthase Complex Auxiliary Component P43 Cleaved Into - Endothelial Monocyte-Activating Polypeptide 2Emap-2Endothelial Monocyte-Activating Polypeptide IiEmap-IiSmall Inducible Cytokine Subfamily E Member 1 |
| Database Links | Reactome: R-MMU-9856649 |
| Cellular Localisation | NucleusCytoplasmCytosolSecretedEndoplasmic ReticulumGolgi ApparatusEnriched In Secretory Vesicles Of Pancreatic Alpha Cells And Secreted From The Pancreas In Response To Low Glucose LevelsSecreted In Response To HypoxiaAlso Secreted In Response To Both Apoptotic And Necrotic Cell Death |
| Alternative ELISA Names | Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 1 ELISA kitMultisynthase Complex Auxiliary Component P43 Cleaved Into - Endothelial Monocyte-Activating Polypeptide 2 ELISA kitEmap-2 ELISA kitEndothelial Monocyte-Activating Polypeptide Ii ELISA kitEmap-Ii ELISA kitSmall Inducible Cytokine Subfamily E Member 1 ELISA kitAimp1 ELISA kitEmap2 ELISA kitScye1 ELISA kit |
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Information sourced from Uniprot.org
