| Tissue Specificity | |
| Post Translational Modifications | Phosphorylation on Ser-1262 is required for interaction with BRCA1. Phosphorylation at Ser-79 by AMPK inactivates enzyme activity. The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity. |
| Function | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. |
| Protein Name | Acetyl-Coa Carboxylase 1Acc1Acc-AlphaAcetyl-Coa Carboxylase 265 |
| Database Links | Reactome: R-MMU-196780Reactome: -MMU-200425Reactome: -MMU-75105 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative ELISA Names | Acetyl-Coa Carboxylase 1 ELISA kitAcc1 ELISA kitAcc-Alpha ELISA kitAcetyl-Coa Carboxylase 265 ELISA kitAcaca ELISA kitAcac ELISA kitGm738 ELISA kit |
| output | |
Information sourced from Uniprot.org
