| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
LOXL1 Blocking Peptide for STJ501634 is synthetically produced from the 570-607 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Loxl1 |
| Gene ID: |
16949 |
| Uniprot ID: |
LOXL1_MOUSE |
| Immunogen Region: |
570-607 |
| Specificity: |
This blocking peptide is recommended for use in combination with LOXL1 antibody, STJ501634 |
| Immunogen: |
Synthetic peptide taken within amino acid region 570-607 on rat LOXL1 protein. |
| Post Translational Modifications | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytic proccessing by a furin-like protease causes removal of N-terminal propeptide resulting in an enzyme largely inactive, but further proteolytic processing by BMP1 results in enzyme activation. |
| Function | Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. Essential for the elastic fiber homeostasis and for their maintenance at adult age. |
| Peptide Name | Lysyl Oxidase Homolog 1Lysyl Oxidase 2Lysyl Oxidase-Like Protein 1 |
| Database Links | Reactome: R-MMU-1566948Reactome: -MMU-2243919 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Peptide Names | Lysyl Oxidase Homolog 1 proteinLysyl Oxidase 2 proteinLysyl Oxidase-Like Protein 1 proteinLoxl1 proteinLox2 proteinLoxl protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
