| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Junctional Adhesion Molecule 1 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | F11R |
| Gene ID: | 50848 |
| Uniprot ID: | JAM1_HUMAN |
| Tissue Specificity | Expressed in endothelium, epithelium and leukocytes (at protein level). |
| Post Translational Modifications | N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions. |
| Function | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. |
| Peptide Name | Junctional Adhesion Molecule A Jam-A Junctional Adhesion Molecule 1 Jam-1 Platelet F11 Receptor Platelet Adhesion Molecule 1 Pam-1 Cd Antigen Cd321 |
| Database Links | Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-2173791 Reactome: R-HSA-420029 |
| Cellular Localisation | Cell Junction Tight Junction Cell Membrane Single-Pass Type I Membrane Protein Localized At Tight Junctions Of Both Epithelial And Endothelial Cells |
| Alternative Peptide Names | Junctional Adhesion Molecule A protein Jam-A protein Junctional Adhesion Molecule 1 protein Jam-1 protein Platelet F11 Receptor protein Platelet Adhesion Molecule 1 protein Pam-1 protein Cd Antigen Cd321 protein F11R protein JAM1 protein JCAM protein UNQ264 protein PRO301 protein |
Information sourced from Uniprot.org