JTB Positive Control for STJ505928 peptide (STJ505717)
SPECIFICATIONS
ImmunogenPurified Jumping Translocation Breakpoint protein.
General Information
| Short Description | JTB Positive Control for STJ505928 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | JTB |
| Gene ID | 10899 |
| Uniprot ID | JTB_HUMAN |
| Immunogen | Purified Jumping Translocation Breakpoint protein. |
| Specificity | This is positive control is recommended for use in combination with JTB antibody STJ505928. |
Additional Info
| Function | Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. |
| Peptide Name | Protein JtbJumping Translocation Breakpoint ProteinProstate Androgen-Regulated ProteinPar Protein |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinMitochondrionCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleDetected At The Centrosome And Along Spindle Fibers During Prophase And MetaphaseDetected At The Midbody During Telophase |
| Alternative Peptide Names | Protein Jtb proteinJumping Translocation Breakpoint Protein proteinProstate Androgen-Regulated Protein proteinPar Protein proteinJTB proteinHSPC222 protein |
Information sourced from Uniprot.org