Human USP8 protein (Recombinant) (N-His) (STJP008938)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human USP8-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | USP8 |
| Gene ID | 9101 |
| Uniprot ID | UBP8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys180-Arg323 |
Additional Info
| Function | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 8Deubiquitinating Enzyme 8Ubiquitin Isopeptidase YHubpyUbiquitin Thioesterase 8Ubiquitin-Specific-Processing Protease 8 |
| Database Links | Reactome: R-HSA-1358803Reactome: R-HSA-4641263Reactome: R-HSA-5689880Reactome: R-HSA-6807004 |
| Cellular Localisation | CytoplasmNucleusEndosome MembranePeripheral Membrane ProteinCell Membrane |
| Alternative Protein Names | Ubiquitin Carboxyl-Terminal Hydrolase 8 proteinDeubiquitinating Enzyme 8 proteinUbiquitin Isopeptidase Y proteinHubpy proteinUbiquitin Thioesterase 8 proteinUbiquitin-Specific-Processing Protease 8 proteinUSP8 proteinKIAA0055 proteinUBPY protein |
Information sourced from Uniprot.org