| Tissue Specificity | Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate, thymus, spleen and peripheral blood leukocytes. |
| Post Translational Modifications | Autophosphorylated. Ubiquitinated.HSP90 activity negatively regulates ubiquitination and degradation. |
| Function | Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules. May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins. Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone-to-protamine transition during spermatogenesis. |
| Protein Name | Testis-Specific Serine/Threonine-Protein Kinase 6Tsk-6Tssk-6Testis-Specific Kinase 6Cancer/Testis Antigen 72Ct72Serine/Threonine-Protein Kinase SstkSmall Serine/Threonine Kinase |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonFlagellum AxonemeNucleusComponent Of The Sperm Flagellar Doublet MicrotubulesAlso Localizes In The Nucleus Of Elongating Spermatids |
| Alternative Protein Names | Testis-Specific Serine/Threonine-Protein Kinase 6 proteinTsk-6 proteinTssk-6 proteinTestis-Specific Kinase 6 proteinCancer/Testis Antigen 72 proteinCt72 proteinSerine/Threonine-Protein Kinase Sstk proteinSmall Serine/Threonine Kinase proteinTSSK6 proteinSSTK proteinFKSG82 protein |
Information sourced from Uniprot.org