Human TNIK protein (Recombinant) (N-His) (STJP010995)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TNIK-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TNIK |
| Gene ID | 23043 |
| Uniprot ID | TNIK_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu1038-Trp1360 |
Additional Info
| Post Translational Modifications | Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction. |
| Function | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. |
| Protein Name | Traf2 And Nck-Interacting Protein Kinase |
| Database Links | Reactome: R-HSA-2559580 |
| Cellular Localisation | NucleusCytoplasmRecycling EndosomeCytoskeletonAssociated With Recycling Endosomes And The Cytoskeletal Fraction Upon Rap2a Overexpression |
| Alternative Protein Names | Traf2 And Nck-Interacting Protein Kinase proteinTNIK proteinKIAA0551 protein |
Information sourced from Uniprot.org