Human TNFRSF10B/DR5/TRAIL-R/2CD262 protein (Recombinant) (C-His) (STJP002613)

SKU:
STJP002613

£72.50 - £156.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human TNFRSF10B/DR5/TRAIL-R/2CD262-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: 1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human TRAIL at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human DR5 with a linear range of 14-56 ng/mL.2.Measured by its ability to inhibit TRAIL-mediated cytotoxici
Gene Symbol: TNFRSF10B
Gene ID: 8795
Uniprot ID: TR10B_HUMAN
Immunogen Region: Ile 56-Glu 182
Immunogen: Active Recombinant Human TNFRSF10B/DR5/TRAIL-R2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ile 56-Glu 182) of human DR5 (Accession #NP_003833.3) fused with a 6×His tag at the C-terminus.
Post Translational Modifications (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 10b
Death Receptor 5
Tnf-Related Apoptosis-Inducing Ligand Receptor 2
Trail Receptor 2
Trail-R2
Cd Antigen Cd262
Database Links Reactome: R-HSA-140534
Reactome: R-HSA-202733
Reactome: R-HSA-3371378
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-6803211
Reactome: R-HSA-69416
Reactome: R-HSA-75158
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 10b protein
Death Receptor 5 protein
Tnf-Related Apoptosis-Inducing Ligand Receptor 2 protein
Trail Receptor 2 protein
Trail-R2 protein
Cd Antigen Cd262 protein
TNFRSF10B protein
DR5 protein
KILLER protein
TRAILR2 protein
TRICK2 protein
ZTNFR9 protein
UNQ160 protein
PRO186 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance