Human TNFRSF10B/DR5/TRAIL-R2 protein (Recombinant) (C-hFc&His) (STJP001381)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenActive Recombinant Human TNFRSF10B/DR5/TRAIL-R2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile56-Glu182) of human DR5/TRAIL R2 (Accession #NP_003833.3) fused with a Fc, 6ÃHis tag at the C-te
General Information
| Short Description | Recombinant-Human TNFRSF10B/DR5/TRAIL-R2-C-hFc&His protein was developed in hek293 cells using the region Ile56-Glu182. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | 1.Measured by its binding ability in a functional ELISA.Immobilized Human TNFRSF10B at 1 Mu g/mL (100 Mu L/well) can bind Human TNFSF10 with a linear range of 0.1-11.7 ng/mL.|2.Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L 92 |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | TNFRSF10B |
| Gene ID | 8795 |
| Uniprot ID | TR10B_HUMAN |
| Immunogen | Active Recombinant Human TNFRSF10B/DR5/TRAIL-R2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile56-Glu182) of human DR5/TRAIL R2 (Accession #NP_003833.3) fused with a Fc, 6ÃHis tag at the C-te |
| Immunogen Region | Ile56-Glu182 |
| Immunogen Sequence | ITQQDLAPQQRAAPQQKRSS PSEGLCPPGHHISEDGRDCI SCKYGQDYSTHWNDLLFCLR CTRCDSGEVELSPCTTTRNT VCQCEEGTFREEDSPEMCRK CRTGCPRGMVKVGDCTPWSD IECVHKE |
Additional Info
| Post Translational Modifications | (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3. |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10bDeath Receptor 5Tnf-Related Apoptosis-Inducing Ligand Receptor 2Trail Receptor 2Trail-R2Cd Antigen Cd262 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-202733Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 10b proteinDeath Receptor 5 proteinTnf-Related Apoptosis-Inducing Ligand Receptor 2 proteinTrail Receptor 2 proteinTrail-R2 proteinCd Antigen Cd262 proteinTNFRSF10B proteinDR5 proteinKILLER proteinTRAILR2 proteinTRICK2 proteinZTNFR9 proteinUNQ160 proteinPRO186 protein |
Information sourced from Uniprot.org