Human TJP1 protein (Recombinant) (N-His) (STJP005213)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TJP1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TJP1 |
| Gene ID | 7082 |
| Uniprot ID | ZO1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Val190 |
Additional Info
| Post Translational Modifications | Phosphorylated at tyrosine redidues in response to epidermal growth factor (EGF). This response is dependent on an intact actin microfilament system. Dephosphorylated by PTPRJ. |
| Function | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling. With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus. May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions. |
| Protein Name | Tight Junction Protein 1Tight Junction Protein Zo-1Zona Occludens Protein 1Zonula Occludens Protein 1 |
| Database Links | Reactome: R-HSA-191650Reactome: R-HSA-2028269Reactome: R-HSA-351906Reactome: R-HSA-8935964Reactome: R-HSA-9705677 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCell JunctionTight JunctionGap JunctionCell ProjectionPodosomeMoves From The Cytoplasm To The Cell Membrane Concurrently With Cell-Cell ContactForms A Condensed Tight Junction-Linked Belt Of Protein During Junction Formation Which Becomes Anchored To The Apical Cell Membrane Via Interaction With PatjAt Podosomal SitesIs Predominantly Localized In The Ring Structure Surrounding The Actin CoreColocalizes With Spef1 At Sites Of Cell-Cell Contact In Intestinal Epithelial Cells |
| Alternative Protein Names | Tight Junction Protein 1 proteinTight Junction Protein Zo-1 proteinZona Occludens Protein 1 proteinZonula Occludens Protein 1 proteinTJP1 proteinZO1 protein |
Information sourced from Uniprot.org