Human Thioredoxin Reductase 1/TXNRD1 (selenocys648cys) protein (Recombinant) (His-Tag) (STJP016982)

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STJP016982
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Host: E.coli
Applications: SDS-PAGE/Enzyme Activity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Thioredoxin Reductase 1/TXNRD1 (selenocys648cys)-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 30% Glycerol, 0.1mM PMSF, 0.1M NaCl
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Specific activity is > 15unit/mg, and was measured in a coupled assay with 5, 5-Dithiobis (2-nitrobenzoic acid) (DTNB) and NADPH. The amount of TNB generated by NADPH was measured in absorbance at 412 nm.
Gene Symbol: TXNRD1
Gene ID: 7296
Uniprot ID: TRXR1_HUMAN
Immunogen Region: 161-649aa
Accession Number: NP_001087240
Immunogen: Human
Immunogen Sequence: YDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVA LREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLG IPGDKEYCIS SDDLFSLPYC PGKTLVVGAS YVALECAGFL AGIGLD
Tissue Specificity Isoform 1: Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4: Widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
Post Translational Modifications Isoform 5: The N-terminus is blocked. ISGylated.
Function Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2). Isoform 1: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. Isoform 5: Enhances the transcriptional activity of the estrogen receptor ESR2 only. Mediates cell death induced by a combination of interferon-beta and retinoic acid.
Protein Name Thioredoxin Reductase 1 - Cytoplasmic
Tr
Gene Associated With Retinoic And Interferon-Induced Mortality 12 Protein
Grim-12
Gene Associated With Retinoic And Ifn-Induced Mortality 12 Protein
Km-102-Derived Reductase-Like Factor
Peroxidase Txnrd1
Thioredoxin Reductase Tr1
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-2408550
Reactome: R-HSA-3299685
Reactome: R-HSA-499943
Reactome: R-HSA-5263617
Reactome: R-HSA-5336415
Reactome: R-HSA-5628897
Reactome: R-HSA-9818027
Cellular Localisation Isoform 1: Cytoplasm
Isoform 4: Cytoplasm
Nucleus
Isoform 5: Cytoplasm
Alternative Protein Names Thioredoxin Reductase 1 - Cytoplasmic protein
Tr protein
Gene Associated With Retinoic And Interferon-Induced Mortality 12 Protein protein
Grim-12 protein
Gene Associated With Retinoic And Ifn-Induced Mortality 12 Protein protein
Km-102-Derived Reductase-Like Factor protein
Peroxidase Txnrd1 protein
Thioredoxin Reductase Tr1 protein
TXNRD1 protein
GRIM12 protein
KDRF protein

Information sourced from Uniprot.org

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