| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | TNC |
| Gene ID: | 3371 |
| Uniprot ID: | TENA_HUMAN |
| Immunogen Region: | Gly23-Ser621 |
| Immunogen: | Recombinant Human Tenascin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly23-Ser621) of human Tenascin (Accession #NP_002151.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | GVLKKVIRHKRQSGVNATLP EENQPVVFNHVYNIKLPVGS QCSVDLESASGEKDLAPPSE PSESFQEHTVDGENQIVFTH RINIPRRACGCAAAPDVKEL LSRLEELENLVSSLREQCTA GAGCCLQPATGRLDTRPFCS GRGNFSTEGCGCVCEPGWKG PNCSEPECPGNCHLRGRCID GQCICDDGFTGEDCSQLACP SDCNDQGKCVNGVCICFEGY AGADCSREICPVPCSEEHG |
| Function | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. |
| Protein Name | TenascinTnCytotactinGmemGp 150-225Glioma-Associated-Extracellular Matrix AntigenHexabrachionJiMyotendinous AntigenNeuronectinTenascin-CTn-C |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000170Reactome: R-HSA-3000178Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Tenascin proteinTn proteinCytotactin proteinGmem proteinGp 150-225 proteinGlioma-Associated-Extracellular Matrix Antigen proteinHexabrachion proteinJi proteinMyotendinous Antigen proteinNeuronectin proteinTenascin-C proteinTn-C proteinTNC proteinHXB protein |
Information sourced from Uniprot.org
