Human TBCB protein (Recombinant) (His-Tag) (STJP017691)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human TBCB-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TBCB |
| Gene ID | 1155 |
| Uniprot ID | TBCB_HUMAN |
| Accession Number | NP_001272 |
| Immunogen | Human |
| Immunogen Region | 1-244aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMEVTGV SAPTVTVFIS SSLNTFRSEK RYSRSLTIAE FKCKLELLVG SPASCMELEL YGVDDKFYSK LDQEDALLGS YPVDDGCRIH VIDHSGARLG EYEDVSRVEK YTISQEAYDQ RQDTVRSFLK RSKLGRYNEE ERAQQEAEAA QRLAEEKAQA SSIPVGSRCE VRAAGQSPRR GTVMYVGLTD FKPGYWIGVR YDEPLGKN |
Additional Info
| Tissue Specificity | Found in most tissues. |
| Post Translational Modifications | Phosphorylation by PAK1 is required for normal function. Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome. (Microbial infection) Glycosylated residues by S.typhimurium protein Ssek1: arginine GlcNAcylation promotes microtubule stability. |
| Function | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. |
| Protein Name | Tubulin-Folding Cofactor BCytoskeleton-Associated Protein 1Cytoskeleton-Associated Protein CkapiTubulin-Specific Chaperone B |
| Database Links | Reactome: R-HSA-389977 |
| Cellular Localisation | CytoplasmCytoskeletonColocalizes With MicrotubulesIn Differentiated NeuronsLocated In The CytoplasmIn Differentiating NeuronsAccumulates At The Growth Cone |
| Alternative Protein Names | Tubulin-Folding Cofactor B proteinCytoskeleton-Associated Protein 1 proteinCytoskeleton-Associated Protein Ckapi proteinTubulin-Specific Chaperone B proteinTBCB proteinCG22 proteinCKAP1 protein |
Information sourced from Uniprot.org