| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.113ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description: | This SYTL2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | SYTL2 |
| Gene ID: | 54843 |
| Uniprot ID: | SYTL2_HUMAN |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells. |
| Post Translational Modifications | Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A. |
| Function | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. |
| Protein Name | Synaptotagmin-Like Protein 2 Breast Cancer-Associated Antigen Sga-72m Exophilin-4 |
| Database Links | Reactome: R-HSA-9824585 |
| Cellular Localisation | Isoform 1: Cytoplasm Cell Membrane Recruited On Vesicular Structures In Cytotoxic T-Lymphocytes (Ctl) By Rab27a Isoform 4: Cell Membrane In The Pancreatic Alpha Cells Distributed In Both Peripheral And Anterior Regions Localizes On The Glucagon Granules In The Cell Periphery |
| Alternative ELISA Names | Synaptotagmin-Like Protein 2 ELISA kit Breast Cancer-Associated Antigen Sga-72m ELISA kit Exophilin-4 ELISA kit SYTL2 ELISA kit KIAA1597 ELISA kit SGA72M ELISA kit SLP2 ELISA kit SLP2A ELISA kit |
| output |
Information sourced from Uniprot.org
