Human sST2 (Interleukin-1 Receptor-Like 1) Antibody Pair (STJAP00174)

SKU:
STJAP00174-50
$674.33
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: Mouse/Mouse
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This sST2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Monoclonal/Monoclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A.
Detection Purification: Protein A.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: IL1RL1
Gene ID: 9173
Uniprot ID: ILRL1_HUMAN
Immunogen: Capture immunogen: Recombinant Human sST2 protein.
Detection Immunogen: Recombinant Human sST2 protein.
Post Translational Modifications Ubiquitinated at Lys-321 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response.
Function Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling.
Protein Name Interleukin-1 Receptor-Like 1
Protein St2
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-6811558
Reactome: R-HSA-9014843 Q01638-2
Cellular Localisation Isoform C: Cell Membrane
Isoform B: Secreted
Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Pair Names Interleukin-1 Receptor-Like 1 antibody pair
Protein St2 antibody pair
IL1RL1 antibody pair
DER4 antibody pair
ST2 antibody pair
T1 antibody pair

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJAP00576 Mouse ST2 (Interleukin-1 Receptor-Like 1) Antibody Pair (STJAP00576) Goat/Goat Mouse ELISA
STJAP00402 Human IL-1R1 (Interleukin-1 Receptor Type 1) Antibody Pair (STJAP00402) Goat/Goat Human ELISA
STJAP00379 Human IL-1R2 (Interleukin-1 Receptor Type 2) Antibody Pair (STJAP00379) Rabbit/Mouse Human ELISA
STJAP00335 Rat IL-1R1 (Interleukin-1 Receptor Type 1) Antibody Pair (STJAP00335) Rabbit/Rabbit Polyclonal/Polyclonal Rat ELISA
STJAP00464 Human IL17RA (Interleukin-17 Receptor A) Antibody Pair (STJAP00464) Rabbit/Rabbit Human ELISA
!