Human sST2 (Interleukin-1 Receptor-Like 1) Antibody Pair (STJAP00174)
SPECIFICATIONS
ClonalityMonoclonal/Monoclonal
HostMouse/Mouse
ConjugationUnconjugated/Biotin
ImmunogenCapture immunogen: Recombinant Human sST2 protein.Detection Immunogen: Recombinant Human sST2 protein.
General Information
| Short Description | This sST2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A.Detection Purification: Protein A. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | IL1RL1 |
| Gene ID | 9173 |
| Uniprot ID | ILRL1_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human sST2 protein.Detection Immunogen: Recombinant Human sST2 protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated at Lys-321 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response. |
| Function | Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling. |
| Protein Name | Interleukin-1 Receptor-Like 1Protein St2 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-6811558Reactome: R-HSA-9014843 Q01638-2 |
| Cellular Localisation | Isoform C: Cell MembraneIsoform B: SecretedCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Pair Names | Interleukin-1 Receptor-Like 1 antibody pairProtein St2 antibody pairIL1RL1 antibody pairDER4 antibody pairST2 antibody pairT1 antibody pair |
Information sourced from Uniprot.org