Human SSBP1 protein (Recombinant) (N-His) (STJP007453)

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STJP007453
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Short Description :Recombinant-Human SSBP1-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:SSBP1
Gene ID:6742
Uniprot ID:SSBP_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:His16-Glu148
Function Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair.
Protein Name Single-Stranded Dna-Binding Protein - Mitochondrial
Mt-Ssb
Mtssb
Pwp1-Interacting Protein 17
Database Links Reactome: R-HSA-2151201
Reactome: R-HSA-9837999
Reactome: R-HSA-9913635
Cellular Localisation Mitochondrion
Mitochondrion Matrix
Mitochondrion Nucleoid
Alternative Protein Names Single-Stranded Dna-Binding Protein - Mitochondrial protein
Mt-Ssb protein
Mtssb protein
Pwp1-Interacting Protein 17 protein
SSBP1 protein
SSBP protein

Information sourced from Uniprot.org