This SPX Sandwich ELISA is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma and other biological fluids.
Applications
ELISA
Reactivity
Human
Sensitivity
46.88pg/mL
Detection Limit
78.13~5000pg/mL
Note
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Product Properties
Storage Instruction
If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
This kit recognizes Human SPX in samples. No significant cross-reactivity or interference between Human SPX and analogues was observed.
Sample Type
Serum, plasma and other biological fluids
Additional Info
Function
Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release. Spexin-1: Acts as a ligand for galanin receptors GALR2 and GALR3. Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes. Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity.
Protein Name
SpexinNpqNeuropeptide QSpexin Hormone Cleaved Into - Spexin-1 - Spexin-2Npq 53-70
Database Links
Cellular Localisation
SecretedExtracellular SpaceCytoplasmic VesicleSecretory VesicleSecreted Via The Classical Er/Golgi-Dependent Pathway Into The Extracellular Medium Largely As A Full-Length Protein Without The Signal PeptideAnd Not As A Hydrolyzed And Amidated PeptideLocalized Extracellularly Surrounding The Villous Trophoblastic CellsDetected In The Serum
