Human SORT1 protein (Recombinant) (N-GST) (STJP005887)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SORT1-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SORT1 |
| Gene ID | 6272 |
| Uniprot ID | SORT_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Trp50-Asp320 |
Additional Info
| Post Translational Modifications | The N-terminal propeptide is cleaved by furin and possibly other homologous proteases. Palmitoylated. Undergoes cysteine S-palmitoylation which promotes the partitioning of the receptor into an endosomal membrane subdomain where it can interact with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus. Phosphorylation at Ser-825 facilitates the interaction with GGA1. |
| Function | Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. |
| Protein Name | Sortilin100 Kda Nt ReceptorGlycoprotein 95Gp95Neurotensin Receptor 3Nt3Ntr3 |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneEndoplasmic Reticulum MembraneNucleus MembraneCell MembraneExtracellular SideLysosome MembraneLocalized To Membranes Of The Endoplasmic ReticulumEndosomesGolgi StackLysosomes And NucleusA Small Fraction Of The Protein Is Also Localized To The Plasma MembraneMay Also Be Found In Slc2a4/Glut4 Storage Vesicles (Gsvs) In AdipocytesLocalization To The Plasma Membrane In Adipocytes May Be Enhanced By Insulin |
| Alternative Protein Names | Sortilin protein100 Kda Nt Receptor proteinGlycoprotein 95 proteinGp95 proteinNeurotensin Receptor 3 proteinNt3 proteinNtr3 proteinSORT1 protein |
Information sourced from Uniprot.org