Human SOAT2 protein (Recombinant) (N-His-KSI) (STJP014297)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHuman
General Information
| Short Description | Recombinant-Human SOAT2-N-His-KSI protein was developed from e.coli and has a target region of N-His-KSI. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 2% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | SOAT2 |
| Gene ID | 8435 |
| Uniprot ID | SOAT2_HUMAN |
| Immunogen | Human |
| Immunogen Region | [Glu2-Phe120] & [Gly253-Arg293] & [Leu370-Arg417] |
Additional Info
| Post Translational Modifications | Polyubiquitinated by AMFR/gp78 at Cys-277, leading to its degradation when the lipid levels are low. Association with AMFR/gp78 is mediated via interaction with INSIG1. High concentration of cholesterol and fatty acid results in Cys-277 oxidation, preventing ubiquitination at the same site, resulting in protein stabilization. Oxidized at Cys-277: high concentration of cholesterol and fatty acid induce reactive oxygen species, which oxidizes Cys-277, preventing ubiquitination at the same site, and resulting in protein stabilization. |
| Function | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. Isoform 2: Has lower enzymatic activity compared to isoform 1. Isoform 3: Has lower enzymatic activity compared to isoform 1. |
| Protein Name | Sterol O-Acyltransferase 2Acyl-Coenzyme A -Cholesterol Acyltransferase 2Acat-2Cholesterol Acyltransferase 2 |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Sterol O-Acyltransferase 2 proteinAcyl-Coenzyme A -Cholesterol Acyltransferase 2 proteinAcat-2 proteinCholesterol Acyltransferase 2 proteinSOAT2 proteinACACT2 proteinACAT2 protein |
Information sourced from Uniprot.org