Human SMAD7 protein (Recombinant) (N-His) (STJP003216)

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STJP003216
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SMAD7-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SMAD7
Gene ID: 4092
Uniprot ID: SMAD7_HUMAN
Immunogen Region: Met1-Arg426
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling.however it affects its ability to regulate transcription. Phosphorylated by PDPK1. Ubiquitinated by WWP1. Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation. In response to TGF-beta, ubiquitinated by SMURF1.which promotes its degradation. Acetylation prevents ubiquitination and degradation mediated by SMURF1.
Function Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members.has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Protein Name Mothers Against Decapentaplegic Homolog 7
Mad Homolog 7
Mothers Against Dpp Homolog 7
Mothers Against Decapentaplegic Homolog 8
Mad Homolog 8
Mothers Against Dpp Homolog 8
Smad Family Member 7
Smad 7
Smad7
Hsmad7
Database Links Reactome: R-HSA-201451
Reactome: R-HSA-2173788
Reactome: R-HSA-2173795
Reactome: R-HSA-2173796
Reactome: R-HSA-5689603
Reactome: R-HSA-5689880
Reactome: R-HSA-877300
Cellular Localisation Nucleus
Cytoplasm
Interaction With Nedd4l Or Rnf111 Induces Translocation From The Nucleus To The Cytoplasm
Tgf-Beta Stimulates Its Translocation From The Nucleus To The Cytoplasm
Pdpk1 Inhibits Its Translocation From The Nucleus To The Cytoplasm In Response To Tgf-Beta
Alternative Protein Names Mothers Against Decapentaplegic Homolog 7 protein
Mad Homolog 7 protein
Mothers Against Dpp Homolog 7 protein
Mothers Against Decapentaplegic Homolog 8 protein
Mad Homolog 8 protein
Mothers Against Dpp Homolog 8 protein
Smad Family Member 7 protein
Smad 7 protein
Smad7 protein
Hsmad7 protein
SMAD7 protein
MADH7 protein
MADH8 protein

Information sourced from Uniprot.org

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