Human SLC27A2 protein (Recombinant) (N-His) (STJP010638)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC27A2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLC27A2 |
| Gene ID | 11001 |
| Uniprot ID | S27A2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly283-Leu620 |
Additional Info
| Function | Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid. May contribute to the synthesis of sphingosine-1-phosphate. Does not activate C24 bile acids, cholate and chenodeoxycholate. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. However, it is not critical for THCA activation and bile synthesis in vivo. Isoform 1: Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids. Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol. Isoform 2: Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 2Arachidonate--Coa LigaseFatty Acid Transport Protein 2Fatp-2Fatty-Acid-Coenzyme A Ligase - Very Long-Chain 1Long-Chain-Fatty-Acid--Coa LigasePhytanate--Coa LigaseSolute Carrier Family 27 Member 2Thca-Coa LigaseVery Long-Chain Acyl-Coa SynthetaseVlacsVlcsVery Long-Chain-Fatty-Acid-Coa Ligase |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-389599Reactome: R-HSA-390247Reactome: R-HSA-6798695Reactome: R-HSA-75105Reactome: R-HSA-9033241 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinPeroxisome MembranePeripheral Membrane ProteinCell MembraneMicrosome |
| Alternative Protein Names | Long-Chain Fatty Acid Transport Protein 2 proteinArachidonate--Coa Ligase proteinFatty Acid Transport Protein 2 proteinFatp-2 proteinFatty-Acid-Coenzyme A Ligase - Very Long-Chain 1 proteinLong-Chain-Fatty-Acid--Coa Ligase proteinPhytanate--Coa Ligase proteinSolute Carrier Family 27 Member 2 proteinThca-Coa Ligase proteinVery Long-Chain Acyl-Coa Synthetase proteinVlacs proteinVlcs proteinVery Long-Chain-Fatty-Acid-Coa Ligase proteinSLC27A2 proteinACSVL1 proteinFACVL1 proteinFATP2 proteinVLACS protein |
Information sourced from Uniprot.org