Human SKP2 protein (Recombinant) (N-His) (STJP005314)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SKP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SKP2 |
| Gene ID | 6502 |
| Uniprot ID | SKP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys43-Leu354 |
Additional Info
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration. Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination. Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. |
| Protein Name | S-Phase Kinase-Associated Protein 2Cyclin-A/Cdk2-Associated Protein P45F-Box Protein Skp2F-Box/Lrr-Repeat Protein 1P45skp2 |
| Database Links | Reactome: R-HSA-174178Reactome: R-HSA-187577Reactome: R-HSA-5689880Reactome: R-HSA-68949Reactome: R-HSA-69231Reactome: R-HSA-8939902Reactome: R-HSA-8951664Reactome: R-HSA-9687136Reactome: R-HSA-9708530Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | S-Phase Kinase-Associated Protein 2 proteinCyclin-A/Cdk2-Associated Protein P45 proteinF-Box Protein Skp2 proteinF-Box/Lrr-Repeat Protein 1 proteinP45skp2 proteinSKP2 proteinFBXL1 protein |
Information sourced from Uniprot.org