Human SFTPA1 protein (Recombinant) (N-His) (STJP011498)

Name: Human SFTPA1 protein (Recombinant) (N-His) (STJP011498)
SKU: STJP011498
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHomo sapiens (Human)

STJP011498

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Short Description	Recombinant-Human SFTPA1-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications	ELISA/Immunogen/SDS-PAGE/WB
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.

Function	In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages. (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen. When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.
Protein Name	Pulmonary Surfactant-Associated Protein A1 Psp-A Pspa Sp-A Sp-A1 35 Kda Pulmonary Surfactant-Associated Protein Alveolar Proteinosis Protein Collectin-4
Database Links	Reactome: R-HSA-166016 Reactome: R-HSA-168179 Reactome: R-HSA-391160 Reactome: R-HSA-5683826 Reactome: R-HSA-5686938 Reactome: R-HSA-5688849 Reactome: R-HSA-5688890
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix Surface Film
Alternative Protein Names	Pulmonary Surfactant-Associated Protein A1 protein Psp-A protein Pspa protein Sp-A protein Sp-A1 protein 35 Kda Pulmonary Surfactant-Associated Protein protein Alveolar Proteinosis Protein protein Collectin-4 protein SFTPA1 protein COLEC4 protein PSAP protein SFTP1 protein SFTPA protein SFTPA1B protein

Information sourced from Uniprot.org