| Short Description : | Recombinant-Active-Human SERPINC1-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit recombinant human Coagulation Factor II/Thrombin cleavage of a fluorogenic peptide substrate BocVPR-AMC. The IC50 value is <5 nM, as measured under the described conditions. |
| Gene Symbol: | SERPINC1 |
| Gene ID: | 462 |
| Uniprot ID: | ANT3_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | His33-Lys464 |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. |
| Protein Name | Antithrombin-IiiAtiiiSerpin C1 |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Protein Names | Antithrombin-Iii proteinAtiii proteinSerpin C1 proteinSERPINC1 proteinAT3 proteinPRO0309 protein |
Information sourced from Uniprot.org
