• Human Serpin G1/Plasma protease C1 inhibitor protein (Recombinant) (C-His) (STJP000970)

Human Serpin G1/Plasma protease C1 inhibitor protein (Recombinant) (C-His) (STJP000970)

SKU:
STJP000970

£106.50 - £359.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Gene Symbol: SERPING1
Gene ID: 710
Uniprot ID: IC1_HUMAN
Immunogen: Recombinant Human SerpinG1/C1 inhibitor/C1IN Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ala500) of human SerpinG1/C1 inhibitor/C1IN (Accession #NP_000053.2) fused with a 6×His tag at the
Immunogen Sequence: MASRLTLLTLLLLLLAGDRA SSNPNATSSSSQDPESLQDR GEGKVATTVISKMLFVEPIL EVSSLPTTNSTTNSATKITA NTTDEPTTQPTTEPTTQPTI QPTQPTTQLPTDSPTQPTTG SFCPGPVTLCSDLESHSTEA VLGDALVDFSLKLYHAFSAM KKVETNMAFSPFSIASLLTQ VLLGAGENTKTNLESILSYP KDFTCVHQALKGFTTKGVTS VSQIFHSPDLAIRDTFVNA
Post Translational Modifications Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor). Can be proteolytically cleaved by E.coli stcE.
Function Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
Protein Name Plasma Protease C1 Inhibitor
C1 Inh
C1inh
C1 Esterase Inhibitor
C1-Inhibiting Factor
Serpin G1
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-140837
Reactome: R-HSA-9657689
Reactome: R-HSA-977606
Cellular Localisation Secreted
Alternative Protein Names Plasma Protease C1 Inhibitor protein
C1 Inh protein
C1inh protein
C1 Esterase Inhibitor protein
C1-Inhibiting Factor protein
Serpin G1 protein
SERPING1 protein
C1IN protein
C1NH protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance