Name: Human Serpin G1/Plasma protease C1 inhibitor protein (Recombinant) (C-His) (STJP000970)
SKU: STJP000970
Availability: InStock

Human Serpin G1/Plasma protease C1 inhibitor protein (Recombinant) (C-His) (STJP000970)

SKU:

STJP000970

£106.50 - £359.50

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 0.1 EU/Mu g of the protein by LAL method.

Gene Symbol:	SERPING1
Gene ID:	710
Uniprot ID:	IC1_HUMAN
Immunogen:	Recombinant Human SerpinG1/C1 inhibitor/C1IN Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ala500) of human SerpinG1/C1 inhibitor/C1IN (Accession #NP_000053.2) fused with a 6×His tag at the
Immunogen Sequence:	MASRLTLLTLLLLLLAGDRA SSNPNATSSSSQDPESLQDR GEGKVATTVISKMLFVEPIL EVSSLPTTNSTTNSATKITA NTTDEPTTQPTTEPTTQPTI QPTQPTTQLPTDSPTQPTTG SFCPGPVTLCSDLESHSTEA VLGDALVDFSLKLYHAFSAM KKVETNMAFSPFSIASLLTQ VLLGAGENTKTNLESILSYP KDFTCVHQALKGFTTKGVTS VSQIFHSPDLAIRDTFVNA

Post Translational Modifications	Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor). Can be proteolytically cleaved by E.coli stcE.
Function	Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
Protein Name	Plasma Protease C1 Inhibitor C1 Inh C1inh C1 Esterase Inhibitor C1-Inhibiting Factor Serpin G1
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-140837 Reactome: R-HSA-9657689 Reactome: R-HSA-977606
Cellular Localisation	Secreted
Alternative Protein Names	Plasma Protease C1 Inhibitor protein C1 Inh protein C1inh protein C1 Esterase Inhibitor protein C1-Inhibiting Factor protein Serpin G1 protein SERPING1 protein C1IN protein C1NH protein

Information sourced from Uniprot.org

Model	Name	Host	Reactivity	Application
STJP000915	Human Serpin C1/Antithrombin-III protein (Recombinant) (C-His) (STJP000915)	HEK293 cells
STJE0004064	Human SERPING1 (Plasma protease C1 inhibitor) Sandwich ELISA Kit (STJE0004064)		Human	ELISA
STJP002632	Human Serpin E1 protein (Recombinant) (C-His) (STJP002632)	HEK293 cells
STJP002704	Human Serpin B3/SCCA-1 protein (Recombinant) (C-His) (STJP002704)	HEK293 cells
STJP002801	Mouse Serpin F1 protein (Recombinant) (C-His) (STJP002801)	HEK293 cells

Human Serpin G1/Plasma protease C1 inhibitor protein (Recombinant) (C-His) (STJP000970)

General Information