| Short Description : | Recombinant-Human Serpin B3/SCCA-1-C-His protein was developed in hek293 cells using the region Met1-Pro390. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1.0 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | SERPINB3 |
| Gene ID: | 6317 |
| Uniprot ID: | SPB3_HUMAN |
| Immunogen: | Recombinant Human Serpin B3/SCCA-1 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Met1-Pro390) of human Serpin B3 (Accession #P29508) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Met1-Pro390 |
| Immunogen Sequence: | MNSLSEANTKFMFDLFQQFR KSKENNIFYSPISITSALGM VLLGAKDNTAQQIKKVLHFD QVTENTTGKAATYHVDRSGN VHHQFQKLLTEFNKSTDAYE LKIANKLFGEKTYLFLQEYL DAIKKFYQTSVESVDFANAP EESRKKINSWVESQTNEKIK NLIPEGNIGSNTTLVLVNAI YFKGQWEKKFNKEDTKEEKF WPNKNTYKSIQMMRQYTSFH FASLEDVQAKVLEIPYKGK |
| Function | May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). |
| Protein Name | Serpin B3Protein T4-ASquamous Cell Carcinoma Antigen 1Scca-1 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmSeems To Also Be Secreted In Plasma By Cancerous Cells But At A Low Level |
| Alternative Protein Names | Serpin B3 proteinProtein T4-A proteinSquamous Cell Carcinoma Antigen 1 proteinScca-1 proteinSERPINB3 proteinSCCA proteinSCCA1 protein |
Information sourced from Uniprot.org
