Human Serpin E1 protein (Recombinant) (C-His) (STJP002632)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Serpin E1 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Val24-Pro402) of human Serpin E1 (Accession #P05121) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Serpin E1-C-His protein was developed in hek293 cells using the region Val24-Pro402. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | SERPINE1 |
| Gene ID | 5054 |
| Uniprot ID | PAI1_HUMAN |
| Immunogen | Recombinant Human Serpin E1 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Val24-Pro402) of human Serpin E1 (Accession #P05121) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Val24-Pro402 |
| Immunogen Sequence | VHHPPSYVAHLASDFGVRVF QQVAQASKDRNVVFSPYGVA SVLAMLQLTTGGETQQQIQA AMGFKIDDKGMAPALRHLYK ELMGPWNKDEISTTDAIFVQ RDLKLVQGFMPHFFRLFRST VKQVDFSEVERARFIINDWV KTHTKGMISNLLGKGAVDQL TRLVLVNALYFNGQWKTPFP DSSTHRRLFHKSDGSTVSVP MMAQTNKFNYTEFTTPDGHY YDILELPYHGDTLSMFIAA |
Additional Info
| Post Translational Modifications | Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond. |
| Function | Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis. |
| Protein Name | Plasminogen Activator Inhibitor 1PaiPai-1Endothelial Plasminogen Activator InhibitorSerpin E1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1368108Reactome: R-HSA-2173796Reactome: R-HSA-3000178Reactome: R-HSA-75205Reactome: R-HSA-9926550 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Plasminogen Activator Inhibitor 1 proteinPai proteinPai-1 proteinEndothelial Plasminogen Activator Inhibitor proteinSerpin E1 proteinSERPINE1 proteinPAI1 proteinPLANH1 protein |
Information sourced from Uniprot.org