| Short Description : | Recombinant-Human Serpin G1/Plasma protease C1 inhibitor-C-His protein was developed in hek293 cells using the region Met1-Ala500. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | SERPING1 |
| Gene ID: | 710 |
| Uniprot ID: | IC1_HUMAN |
| Immunogen: | Recombinant Human SerpinG1/C1 inhibitor/C1IN Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ala500) of human SerpinG1/C1 inhibitor/C1IN (Accession #NP_000053.2) fused with a 6×His tag at the |
| Immunogen Region: | Met1-Ala500 |
| Immunogen Sequence: | MASRLTLLTLLLLLLAGDRA SSNPNATSSSSQDPESLQDR GEGKVATTVISKMLFVEPIL EVSSLPTTNSTTNSATKITA NTTDEPTTQPTTEPTTQPTI QPTQPTTQLPTDSPTQPTTG SFCPGPVTLCSDLESHSTEA VLGDALVDFSLKLYHAFSAM KKVETNMAFSPFSIASLLTQ VLLGAGENTKTNLESILSYP KDFTCVHQALKGFTTKGVTS VSQIFHSPDLAIRDTFVNA |
| Post Translational Modifications | Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor). Cleaved by C1S in vitro. (Microbial infection) Can be proteolytically cleaved by E.coli stcE. |
| Function | Serine protease inhibitor, which acrs as a regulator of the classical complement pathway. Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May also regulate blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. |
| Protein Name | Plasma Protease C1 InhibitorC1 InhC1inhC1 Esterase InhibitorC1-Inhibiting FactorSerpin G1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-9657689Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Plasma Protease C1 Inhibitor proteinC1 Inh proteinC1inh proteinC1 Esterase Inhibitor proteinC1-Inhibiting Factor proteinSerpin G1 proteinSERPING1 proteinC1IN proteinC1NH protein |
Information sourced from Uniprot.org
