Human Serpin E1 protein (Recombinant) (C-His) (STJP002632)

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STJP002632
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.2 Mu m filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: SERPINE1
Gene ID: 5054
Uniprot ID: PAI1_HUMAN
Immunogen Region: Val24-Pro402
Immunogen: Recombinant Human Serpin E1 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Val24-Pro402) of human Serpin E1 (Accession #P05121) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: VHHPPSYVAHLASDFGVRVF QQVAQASKDRNVVFSPYGVA SVLAMLQLTTGGETQQQIQA AMGFKIDDKGMAPALRHLYK ELMGPWNKDEISTTDAIFVQ RDLKLVQGFMPHFFRLFRST VKQVDFSEVERARFIINDWV KTHTKGMISNLLGKGAVDQL TRLVLVNALYFNGQWKTPFP DSSTHRRLFHKSDGSTVSVP MMAQTNKFNYTEFTTPDGHY YDILELPYHGDTLSMFIAA
Post Translational Modifications Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.
Function Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis.
Protein Name Plasminogen Activator Inhibitor 1
Pai
Pai-1
Endothelial Plasminogen Activator Inhibitor
Serpin E1
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-1368108
Reactome: R-HSA-2173796
Reactome: R-HSA-3000178
Reactome: R-HSA-75205
Cellular Localisation Secreted
Alternative Protein Names Plasminogen Activator Inhibitor 1 protein
Pai protein
Pai-1 protein
Endothelial Plasminogen Activator Inhibitor protein
Serpin E1 protein
SERPINE1 protein
PAI1 protein
PLANH1 protein

Information sourced from Uniprot.org

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