Human SEC16A protein (Recombinant) (N-His) (STJP016344)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SEC16A-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | SEC16A |
| Gene ID | 9919 |
| Uniprot ID | SC16A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser1612-Gly1890 |
Additional Info
| Function | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Mediates the recruitment of MIA3/TANGO to ERES. Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane. Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183. Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes. |
| Protein Name | Protein Transport Protein Sec16aSec16 Homolog AP250 |
| Database Links | Reactome: R-HSA-204005 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinGolgi Apparatus MembraneCytoplasmPerinuclear RegionCytosolMicrosome MembraneSar1a Activity Is Required To Maintain Sec16a Localization At Discrete Locations On The Er Membrane Perhaps By Preventing Its DissociationLocalizes To Endoplasmic Reticulum Exit Sites (Eres)Also Known As Transitional Endoplasmic Reticulum (Ter)Mia3 And Lrrk2 Are Required For Its Proper Localization To EresRecruited To Microsomal Membrane In Sar1-Dependent Manner |
| Alternative Protein Names | Protein Transport Protein Sec16a proteinSec16 Homolog A proteinP250 proteinSEC16A proteinKIAA0310 proteinSEC16 proteinSEC16L protein |
Information sourced from Uniprot.org