Human SCNN1g (Amiloride Sensitive Sodium Channel Subunit Gamma) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018430)

Human SCNN1g (Amiloride Sensitive Sodium Channel Subunit Gamma) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018430)

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STJE0018430
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.113ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This SCNN1g Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: SCNN1G
Gene ID: 6340
Uniprot ID: SCNNG_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in kidney (at protein level).
Post Translational Modifications Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. Ubiquitinated.this targets individual subunits for endocytosis and proteasome-mediated degradation. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.
Function Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Protein Name Amiloride-Sensitive Sodium Channel Subunit Gamma
Epithelial Na(+ Channel Subunit Gamma
Enacg
Gamma-Enac
Gamma-Nach
Nonvoltage-Gated Sodium Channel 1 Subunit Gamma
Scneg
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-9730628
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Apical Membrane Of Epithelial Cells
Alternative ELISA Names Amiloride-Sensitive Sodium Channel Subunit Gamma ELISA kit
Epithelial Na(+ Channel Subunit Gamma ELISA kit
Enacg ELISA kit
Gamma-Enac ELISA kit
Gamma-Nach ELISA kit
Nonvoltage-Gated Sodium Channel 1 Subunit Gamma ELISA kit
Scneg ELISA kit
SCNN1G ELISA kit
output

Information sourced from Uniprot.org

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