Human SCN9A protein (Recombinant) (N-His) (STJP008321)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SCN9A-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SCN9A |
| Gene ID | 6335 |
| Uniprot ID | SCN9A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu1761-Lys1918 |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. Ubiquitinated by NEDD4L.which may promote its endocytosis. |
| Function | Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain. |
| Protein Name | Sodium Channel Protein Type 9 Subunit AlphaNeuroendocrine Sodium ChannelHne-NaPeripheral Sodium Channel 1Pn1Sodium Channel Protein Type Ix Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.7 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionNeuron ProjectionAxonLocalizes To Neuron TerminalsAlso Detected At Nodes Of Ranvier |
| Alternative Protein Names | Sodium Channel Protein Type 9 Subunit Alpha proteinNeuroendocrine Sodium Channel proteinHne-Na proteinPeripheral Sodium Channel 1 proteinPn1 proteinSodium Channel Protein Type Ix Subunit Alpha proteinVoltage-Gated Sodium Channel Subunit Alpha Nav1.7 proteinSCN9A proteinNENA protein |
Information sourced from Uniprot.org