SDS-PAGE gel of recombinant human REXO2 protein under reducing conditions Coomassie blue stain

Human REXO2 protein (Recombinant) (His-Tag) (STJP018259)

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STJP018259
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Short Description :Recombinant-Human REXO2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:REXO2
Gene ID:25996
Uniprot ID:ORN_HUMAN
Accession Number:NP_056338
Immunogen:Human
Immunogen Region:26-237aa
Immunogen Sequence:VREGGAA MAAGESMAQR MVWVDLEMTG LDIEKDQIIE MACLITDSDL NILAEGPNLI IKQPDELLDS MSDWCKEHHG KSGLTKAVKE STITLQQAEY EFLSFVRQQT PPGLCPLAGN SVHEDKKFLD KYMPQFMKHL HYRIIDVSTV KELCRRWYPE EYEFAPKKAA SHRALDDISE SIKELQFYRN NIFKKKIDEK KRKIIE
Tissue Specificity Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus.
Function 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development. Isoform 3: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides.
Protein Name Oligoribonuclease - Mitochondrial
Rna Exonuclease 2 Homolog
Small Fragment Nuclease
Database Links Reactome: R-HSA-9836573
Cellular Localisation Mitochondrion Intermembrane Space
Mitochondrion Matrix
Mitochondrion
Cytoplasm
Nucleus
Isoform 3: Cytoplasm
Alternative Protein Names Oligoribonuclease - Mitochondrial protein
Rna Exonuclease 2 Homolog protein
Small Fragment Nuclease protein
REXO2 protein
SFN protein
SMFN protein
CGI-114 protein

Information sourced from Uniprot.org

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