Human RAP1B protein (Recombinant) (His-Tag) (STJP017029)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RAP1B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM MES buffer (pH 5.0) containing 0.2M NaCl, 5mM DTT, 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAP1B |
| Gene ID | 5908 |
| Uniprot ID | RAP1B_HUMAN |
| Accession Number | NP_056461 |
| Immunogen | Human |
| Immunogen Region | 1-181aa |
| Immunogen Sequence |
Additional Info
| Function | GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. |
| Protein Name | Ras-Related Protein Rap-1bGtp-Binding Protein Smg P21b |
| Database Links | Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-392517Reactome: R-HSA-5674135Reactome: R-HSA-6798695Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8875555Reactome: R-HSA-8950505Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell MembraneCytoplasmCytosolCell JunctionMay Shuttle Between Plasma Membrane And CytosolPresence Of Krit1 And Cdh5 Is Required For Its Localization To The Cell Junction |
| Alternative Protein Names | Ras-Related Protein Rap-1b proteinGtp-Binding Protein Smg P21b proteinRAP1B proteinOK proteinSW-cl.11 protein |
Information sourced from Uniprot.org