Human RALA protein (Recombinant) (N-His) (STJP003998)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RALA-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RALA |
| Gene ID | 5898 |
| Uniprot ID | RALA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Leu206 |
Additional Info
| Function | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody. During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1. |
| Protein Name | Ras-Related Protein Ral-A |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-171007Reactome: R-HSA-8950505 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCleavage FurrowMidbodyMidbody RingMitochondrionPredominantly At The Cell Surface In The Absence Of LpaIn The Presence Of LpaColocalizes With Lpar1 And Lpar2 In Endocytic VesiclesMay Colocalize With Cntrl/Centriolin At The Midbody RingHoweverLocalization At The Midbody At Late Cytokinesis Was Not ConfirmedRelocalizes To The Mitochondrion During Mitosis Where It Regulates Mitochondrial Fission |
| Alternative Protein Names | Ras-Related Protein Ral-A proteinRALA proteinRAL protein |
Information sourced from Uniprot.org