Human RAB32 protein (Recombinant) (His-Tag) (STJP017371)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RAB32-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 50% Glycerol, 200mM NaCl, 2mM EDTA |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB32 |
| Gene ID | 10981 |
| Uniprot ID | RAB32_HUMAN |
| Accession Number | NP_006825 |
| Immunogen | Human |
| Immunogen Region | 1-225aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2. |
| Protein Name | Ras-Related Protein Rab-32 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | MitochondrionMitochondrion Outer MembraneLipid-AnchorCytoplasmic VesiclePhagosomePhagosome MembraneCytoplasmic SideMelanosomeMelanosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosisThe Bloc-3 ComplexA Heterodimer Of Hps1 And Hps4 Promotes Its Membrane Localization |
| Alternative Protein Names | Ras-Related Protein Rab-32 proteinRAB32 protein |
Information sourced from Uniprot.org