| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human PRLR/Prolactin Receptor at 1 Mu g/mL (100 Mu L/well) can bind Prolactin Receptor Rabbit mAb with a linear range of 0.67-3.45 ng/mL. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | PRLR |
| Gene ID: | 5618 |
| Uniprot ID: | PRLR_HUMAN |
| Immunogen: | Recombinant Human Prolactin receptor/PRL-R Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln25-Asp234) of human PRLR/Prolactin Receptor (Accession #NP_000940.1) fused with a 6×His tag at the C-terminu |
| Immunogen Region: | Gln25-Asp234 |
| Immunogen Sequence: | QLPPGKPEIFKCRSPNKETF TCWWRPGTDGGLPTNYSLTY HREGETLMHECPDYITGGPN SCHFGKQYTSMWRTYIMMVN ATNQMGSSFSDELYVDVTYI VQPDPPLELAVEVKQPEDRK PYLWIKWSPPTLIDLKTGWF TLLYEIRLKPEKAAEWEIHF AGQQTEFKILSLHPGQKYLV QVRCKPDHGYWSAWSPATFI QIPSDFTMND |
| Function | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. |
| Protein Name | Prolactin ReceptorPrl-R |
| Database Links | Reactome: R-HSA-1170546Reactome: R-HSA-982772 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinIsoform 7: Secreted |
| Alternative Protein Names | Prolactin Receptor proteinPrl-R proteinPRLR protein |
Information sourced from Uniprot.org
