Human Prolactin receptor/PRL-R protein (Recombinant) (C-His) (STJP002577)

SKU:
STJP002577

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Prolactin receptor/PRL-R-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human PRLR/Prolactin Receptor at 1 Mu g/mL (100 Mu L/well) can bind Prolactin Receptor Rabbit monoclonal antibody with a linear range of 0.67-3.45 ng/mL.
Gene Symbol: PRLR
Gene ID: 5618
Uniprot ID: PRLR_HUMAN
Immunogen Region: Gln25-Asp234
Immunogen: Recombinant Human Prolactin receptor/PRL-R Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln25-Asp234) of human PRLR/Prolactin Receptor (Accession #NP_000940.1) fused with a 6×His tag at the C-terminu
Function This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Protein Name Prolactin Receptor
Prl-R
Database Links Reactome: R-HSA-1170546
Reactome: R-HSA-982772
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Isoform 7: Secreted
Alternative Protein Names Prolactin Receptor protein
Prl-R protein
PRLR protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance