• Human Progranulin/PGRN/GRN protein (Recombinant) (C-His) (STJP000961)

Human Progranulin/PGRN/GRN protein (Recombinant) (C-His) (STJP000961)

SKU:
STJP000961

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Progranulin/PGRN/GRN-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: GRN
Gene ID: 2896
Uniprot ID: GRN_HUMAN
Immunogen: Recombinant Human Progranulin/PGRN/GRN Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Thr18-Leu593) of human Granulin/GRN/Progranulin (Accession #NP_002078.1) fused with a 6Ă—His tag at the C-terminus.
Tissue Specificity In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
Post Translational Modifications Cleaved by ELANE.proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production.granulin-3 and granulin-4 are resistant to ELANE. Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome.
Function Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity. Granulin-4: Promotes proliferation of the epithelial cell line A431 in culture. Granulin-3: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. Granulin-7: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.
Protein Name Progranulin
Pgrn
Acrogranin
Epithelin Precursor
Glycoprotein Of 88 Kda
Gp88
Glycoprotein 88
Granulin Precursor
Pc Cell-Derived Growth Factor
Pcdgf
Proepithelin
Pepi Cleaved Into - Paragranulin - Granulin-1
Granulin G - Granulin-2
Granulin F - Granulin-3
Epithelin-2
Granulin B - Granulin-4
Epithelin-1
Granulin A - Granulin-5
Granulin C - Granulin-6
Granulin D - Granulin-7
Granulin E
Database Links Reactome: R-HSA-6798695
Cellular Localisation Secreted
Lysosome
Endocytosed By Sort1 And Delivred To Lysosomes
Targeted To Lysosome By Psap Via M6pr And Lrp1
In Both Biosynthetic And Endocytic Pathways
Co-Localized With Gba1 In The Intracellular Trafficking Compartments Until To Lysosome
Alternative Protein Names Progranulin protein
Pgrn protein
Acrogranin protein
Epithelin Precursor protein
Glycoprotein Of 88 Kda protein
Gp88 protein
Glycoprotein 88 protein
Granulin Precursor protein
Pc Cell-Derived Growth Factor protein
Pcdgf protein
Proepithelin protein
Pepi Cleaved Into - Paragranulin - Granulin-1 protein
Granulin G - Granulin-2 protein
Granulin F - Granulin-3 protein
Epithelin-2 protein
Granulin B - Granulin-4 protein
Epithelin-1 protein
Granulin A - Granulin-5 protein
Granulin C - Granulin-6 protein
Granulin D - Granulin-7 protein
Granulin E protein
GRN protein

Information sourced from Uniprot.org

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