Human GRN protein (Recombinant) (N-His) (STJP006601)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GRN-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GRN |
| Gene ID | 2896 |
| Uniprot ID | GRN_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr18-Asp363 |
Additional Info
| Post Translational Modifications | Cleaved by ELANE.proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production.granulin-3 and granulin-4 are resistant to ELANE. Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome. |
| Function | Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity. Granulin-4: Promotes proliferation of the epithelial cell line A431 in culture. Granulin-3: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. Granulin-7: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. |
| Protein Name | ProgranulinPgrnAcrograninEpithelin PrecursorGlycoprotein Of 88 KdaGp88Glycoprotein 88Granulin PrecursorPc Cell-Derived Growth FactorPcdgfProepithelinPepi Cleaved Into - Paragranulin - Granulin-1Granulin G - Granulin-2Granulin F - Granulin-3Epithelin-2Granulin B - Granulin-4Epithelin-1Granulin A - Granulin-5Granulin C - Granulin-6Granulin D - Granulin-7Granulin E |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedLysosomeEndocytosed By Sort1 And Delivred To LysosomesTargeted To Lysosome By Psap Via M6pr And Lrp1In Both Biosynthetic And Endocytic PathwaysCo-Localized With Gba1 In The Intracellular Trafficking Compartments Until To Lysosome |
| Alternative Protein Names | Progranulin proteinPgrn proteinAcrogranin proteinEpithelin Precursor proteinGlycoprotein Of 88 Kda proteinGp88 proteinGlycoprotein 88 proteinGranulin Precursor proteinPc Cell-Derived Growth Factor proteinPcdgf proteinProepithelin proteinPepi Cleaved Into - Paragranulin - Granulin-1 proteinGranulin G - Granulin-2 proteinGranulin F - Granulin-3 proteinEpithelin-2 proteinGranulin B - Granulin-4 proteinEpithelin-1 proteinGranulin A - Granulin-5 proteinGranulin C - Granulin-6 proteinGranulin D - Granulin-7 proteinGranulin E proteinGRN protein |
Information sourced from Uniprot.org