Human PLAU/uPA (pro form) protein (Recombinant) (C-His) (STJP020048)

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STJP020048-100
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.22 Mu m filtered solution in 25 mM HEPES, 150 mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: PLAU
Gene ID: 5328
Uniprot ID: UROK_HUMAN
Immunogen Region: Ser21-Leu431
Immunogen: Recombinant Human PLAU/uPA Protein (pro form) is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser21-Leu431) of Human PLAU/uPA (pro form) (Accession #P00749-1) fused with a C-His tag at the C-terminus.
Immunogen Sequence: SNELHQVPSNCDCLNGGTCV SNKYFSNIHWCNCPKKFGGQ HCEIDKSKTCYEGNGHFYRG KASTDTMGRPCLPWNSATVL QQTYHAHRSDALQLGLGKHN YCRNPDNRRRPWCYVQVGLK LLVQECMVHDCADGKKPSSP PEELKFQCGQKTLRPRFKII GGEFTTIENQPWFAAIYRRH RGGSVTYVCGGSLISPCWVI SATHCFIDYPKKEDYIVYLG RSRLNSNTQGEMKFEVENL
Tissue Specificity Expressed in the prostate gland and prostate cancers.
Post Translational Modifications Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4.
Function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Protein Name Urokinase-Type Plasminogen Activator
U-Plasminogen Activator
Upa Cleaved Into - Urokinase-Type Plasminogen Activator Long Chain A - Urokinase-Type Plasminogen Activator Short Chain A - Urokinase-Type Plasminogen Activator Chain B
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-75205
Cellular Localisation Secreted
Alternative Protein Names Urokinase-Type Plasminogen Activator protein
U-Plasminogen Activator protein
Upa Cleaved Into - Urokinase-Type Plasminogen Activator Long Chain A - Urokinase-Type Plasminogen Activator Short Chain A - Urokinase-Type Plasminogen Activator Chain B protein
PLAU protein

Information sourced from Uniprot.org

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