Human NUAK2 protein (Recombinant) (N-His) (STJP016380)

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STJP016380
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NUAK2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for further information.
Gene Symbol: NUAK2
Gene ID: 81788
Uniprot ID: NUAK2_HUMAN
Immunogen Region: Lys46-Gly306
Immunogen: Homo sapiens (Human)
Function Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway.
Protein Name Nuak Family Snf1-Like Kinase 2
Omphalocele Kinase 2
Snf1/Amp Kinase-Related Kinase
Snark
Database Links
Cellular Localisation
Alternative Protein Names Nuak Family Snf1-Like Kinase 2 protein
Omphalocele Kinase 2 protein
Snf1/Amp Kinase-Related Kinase protein
Snark protein
NUAK2 protein
OMPHK2 protein
SNARK protein

Information sourced from Uniprot.org

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